MolNFT v1 · #29996 · protein + DNA

NMR solution structure of the bicoid homeodomain bound to the consensus DNA binding site taatcc

1ZQ3 · 5'-D(*GP*CP*TP*CP*TP*AP*AP*TP*CP*CP*CP*CP*G)-3': “NMR solution structure of the bicoid homeodomain bound to the consensus DNA binding site taatcc”. Solution nmr, 3 pockets (best druggability 0.49). MolNFT v1 #29996 on GenesisL1: 3D…

PDB: 1ZQ3
Type: protein + DNA
Length: 94 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*GP*CP*TP*CP*TP*AP*AP*TP*CP*CP*CP*CP*G)-3'…
UniProt: Q9UAM0
Pockets: 3 · best druggability 0.49

Structure

solution nmr · 3 distinct chains · 62% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5'-D(GPCPTPCPTPAPAPTPCPCPCPCP*G)-3'	dna	13	—	—
B	5'-D(CPGPGPGPGPAPTPTPAPGPAPGP*C)-3'	dna	13	—	—
P	Homeotic bicoid protein	protein	68	62% helix, 0% strand	Q9UAM0

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	173	0.49	0.77	23	empty
2	67	0.41	0.81	14	empty
3	69	0.31	0.74	12	empty

Interfaces

3 interfaces between chains.

B–P · 655 Å² buried · 19 hydrogen bonds · protein-nucleic
A–B · 586 Å² buried · 60 hydrogen bonds · nucleic-nucleic
A–P · 462 Å² buried · 7 hydrogen bonds · protein-nucleic

Compared structures

1ZQ3 · NMR Solution Structure of the Bicoid Homeodomain Bound to the Consensus DNA Binding Site… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UAM0
Elsewhere: RCSB PDB 1ZQ3 · PDBe 1ZQ3 · UniProt Q9UAM0

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