MolNFT v1 · #29968 · protein

Structure of the mediator subunit cyclin C

1ZP2 · RNA polymerase II holoenzyme cyclin-like subunit: “Structure of the mediator subunit cyclin C”. X-ray diffraction, 2 pockets (best druggability 0.45). MolNFT v1 #29968 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1ZP2
Type: protein
Length: 227 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA polymerase II holoenzyme cyclin-like subunit
UniProt: O94503
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 64% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA polymerase II holoenzyme cyclin-like subunit	protein	227	64% helix, 0% strand	O94503

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	143	0.45	0.76	25	empty
2	78	0.34	0.75	13	empty

Compared structures

1ZP2 · Structure of the Mediator subunit cyclin C · the same entry in another collection · chain A against A, TM-score 1.00
O94503 · AlphaFold monomer V2.0 prediction for RNA polymerase II holoenzyme cyclin-like subunit… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O94503
Elsewhere: RCSB PDB 1ZP2 · PDBe 1ZP2 · UniProt O94503

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