MolNFT v1 · #29951 · protein
Crystal structure of protein kinase CK2 in complex with tbb- derivatives inhibitors
1ZOH · Protein kinase CK2, alpha subunit: “Crystal structure of protein kinase CK2 in complex with tbb- derivatives inhibitors”. X-ray diffraction, 3 ligands (K44, NA, CL), 1 pocket (best druggability 0.67). MolNFT v1 #29951 on GenesisL1…
- PDB
- 1ZOH
- Type
- protein
- Length
- 326 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein kinase CK2, alpha subunit
- EC
- 2.7.1.37
- UniProt
- P28523
- Ligands
- K44, NA, CL
- Pockets
- 1 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein kinase CK2, alpha subunit (EC 2.7.1.37) | protein | 326 | 43% helix, 15% strand | P28523 |
Ligands and binding sites
- K44 · 5,6,7,8-tetrabromo-1-methyl-2,3-dihydro-1H-imidazo[1,2-a]benzimidazole · ligand · chains A
- NA · Sodium ion · metal · chains A
- CL · Chloride ion · ion · 2 copies · chains A
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 392 | 0.67 | 0.80 | 44 | NA, CL, K44 |
Compared structures
- 1ZOH · Crystal structure of protein kinase CK2 in complex with TBB-derivatives inhibitors · the same entry in another collection · chain A against A, TM-score 1.00
- P28523 · AlphaFold monomer V2.0 prediction for casein kinase II subunit alpha (P28523) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28523
- Elsewhere: RCSB PDB 1ZOH · PDBe 1ZOH · UniProt P28523
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.