MolNFT v1 · #29950 · protein
Crystal structure of protein kinase CK2 in complex with tbb- derivatives
1ZOG · Protein kinase CK2, alpha subunit: “Crystal structure of protein kinase CK2 in complex with tbb- derivatives”. X-ray diffraction, 1 ligand (K37), 1 pocket (best druggability 0.68). MolNFT v1 #29950 on GenesisL1: 3D structure…
- PDB
- 1ZOG
- Type
- protein
- Length
- 325 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein kinase CK2, alpha subunit
- EC
- 2.7.1.37
- UniProt
- P28523
- Ligands
- K37
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein kinase CK2, alpha subunit (EC 2.7.1.37) | protein | 325 | 40% helix, 15% strand | P28523 |
Ligands and binding sites
- K37 · 4,5,6,7-tetrabromo-2-(methylsulfanyl)-1H-benzimidazole · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 354 | 0.68 | 0.81 | 47 | K37 |
Compared structures
- 1ZOG · Crystal structure of protein kinase CK2 in complex with TBB-derivatives · the same entry in another collection · chain A against A, TM-score 1.00
- P28523 · AlphaFold monomer V2.0 prediction for casein kinase II subunit alpha (P28523) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28523
- Elsewhere: RCSB PDB 1ZOG · PDBe 1ZOG · UniProt P28523
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