MolNFT v1 · #29814 · protein

Crystal structure of transcriptional regulator from bacillus cereus atcc 14579

1ZK8 · Transcriptional regulator, tetr family: “Crystal structure of transcriptional regulator from bacillus cereus atcc 14579”. X-ray diffraction, 4 pockets (best druggability 0.71). MolNFT v1 #29814 on GenesisL1: 3D structure, binding…

PDB: 1ZK8
Type: protein
Length: 353 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional regulator, tetr family
UniProt: Q815X4
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional regulator, tetr family	protein	177	79% helix, 0% strand	Q815X4
B	Transcriptional regulator, tetr family	protein	176	78% helix, 0% strand	Q815X4

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	172	0.71	0.89	24	empty
2	175	0.70	0.88	25	empty
3	281	0.57	0.77	33	empty
4	88	0.44	0.80	19	empty

Interfaces

1 interface between chains.

A–B · 1729 Å² buried · 22 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

1ZK8 · Crystal structure of transcriptional regulator from Bacillus cereus ATCC 14579 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q815X4
Elsewhere: RCSB PDB 1ZK8 · PDBe 1ZK8 · UniProt Q815X4

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