MolNFT v1 · #29713 · protein
Structural and biochemical basis for selective repression of the orphan nuclear receptor lrh-1 by shp
1ZH7 · Orphan nuclear receptor NR5A2: “Structural and biochemical basis for selective repression of the orphan nuclear receptor lrh-1 by shp”. X-ray diffraction, 10 pockets (best druggability 0.87). MolNFT v1 #29713 on GenesisL1: 3D…
- PDB
- 1ZH7
- Type
- protein
- Length
- 508 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Orphan nuclear receptor NR5A2; Nuclear receptor subfamily 0, group B, member 2
- UniProt
- P45448, P97947
- Pockets
- 10 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Orphan nuclear receptor NR5A2 | protein | 243 | 69% helix, 2% strand | P45448 |
| C, D | Nuclear receptor subfamily 0, group B, member 2 | protein | 11 | 64% helix, 0% strand | P97947 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 343 | 0.87 | 0.96 | 31 | empty |
| 2 | 353 | 0.87 | 0.95 | 31 | empty |
| 3 | 146 | 0.70 | 0.89 | 22 | empty |
| 4 | 138 | 0.65 | 0.87 | 20 | empty |
| 5 | 275 | 0.61 | 0.79 | 43 | empty |
Interfaces
3 interfaces between chains.
- A–C · 519 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 517 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 352 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1ZH7 · Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor… · the same entry in another collection · chain A against A, TM-score 1.00
- P45448 · AlphaFold monomer V2.0 prediction for nuclear receptor subfamily 5 group a member 2… · a predicted model of the same protein · chain A against A, TM-score 0.97
- P97947 · AlphaFold monomer V2.0 prediction for nuclear receptor subfamily 0 group B member 2… · a predicted model of the same protein · chain C against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P45448
- Every structure of UniProt P97947
- Elsewhere: RCSB PDB 1ZH7 · PDBe 1ZH7 · UniProt P45448 · UniProt P97947
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