MolNFT v1 · #29705 · protein
Structural and biochemical basis for selective repression of the orphan nuclear receptor lrh-1 by shp
1ZGY · Peroxisome proliferator activated receptor gamma: “Structural and biochemical basis for selective repression of the orphan nuclear receptor lrh-1 by shp”. X-ray diffraction, 1 ligand (BRL), 2 pockets (best druggability 0.83). MolNFT…
- PDB
- 1ZGY
- Type
- protein
- Length
- 284 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxisome proliferator activated receptor gamma; Nuclear receptor subfamily 0, group B…
- UniProt
- P37231, P97947
- Ligands
- BRL
- Pockets
- 2 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 62% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peroxisome proliferator activated receptor gamma | protein | 272 | 62% helix, 5% strand | P37231 |
| B | Nuclear receptor subfamily 0, group B, member 2 | protein | 12 | 58% helix, 0% strand | P97947 |
Ligands and binding sites
- BRL · 2,4-thiazolidiinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-(9CL) · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 674 | 0.83 | 0.87 | 68 | BRL |
| 2 | 97 | 0.43 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 574 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1ZGY · Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor… · the same entry in another collection · chain A against A, TM-score 1.00
- P97947 · AlphaFold monomer V2.0 prediction for nuclear receptor subfamily 0 group B member 2… · a predicted model of the same protein · chain B against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37231
- Every structure of UniProt P97947
- Elsewhere: RCSB PDB 1ZGY · PDBe 1ZGY · UniProt P37231 · UniProt P97947
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.