MolNFT v1 · #29516 · protein

Structure basis for endosomal targeting by the BRO1 domain

1ZB1 · BRO1 protein: “Structure basis for endosomal targeting by the BRO1 domain”. X-ray diffraction, 4 pockets (best druggability 0.54). MolNFT v1 #29516 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1ZB1
Type: protein
Length: 734 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BRO1 protein
UniProt: P48582
Pockets: 4 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 67% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	BRO1 protein	protein	367	67% helix, 2% strand	P48582

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	124	0.54	0.82	21	empty
2	244	0.50	0.75	36	empty
3	71	0.33	0.75	15	empty
4	56	0.28	0.73	11	empty

Interfaces

1 interface between chains.

A–B · 483 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

1ZB1 · Structure basis for endosomal targeting by the Bro1 domain · the same entry in another collection · chain A against A, TM-score 1.00
P48582 · AlphaFold monomer V2.0 prediction for vacuolar-sorting protein BRO1 (P48582) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48582
Elsewhere: RCSB PDB 1ZB1 · PDBe 1ZB1 · UniProt P48582

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