MolNFT v1 · #29512 · protein
Ribosomal protein L10-L12(NTD) complex, space group P21
1ZAV · 50S ribosomal protein L10: “Ribosomal protein L10-L12(NTD) complex, space group P21”. X-ray diffraction, 1 pocket (best druggability 0.42). MolNFT v1 #29512 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1ZAV
- Type
- protein
- Length
- 353 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 50S ribosomal protein L10; 50S ribosomal protein L7/L12
- UniProt
- P29394, P29396
- Pockets
- 1 · best druggability 0.42
Structure
x-ray diffraction · 4 distinct chains · 66% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 50S ribosomal protein L10 | protein | 178 | 60% helix, 15% strand | P29394 |
| U, V, W | 50S ribosomal protein L7/L12 | protein | 30 | 80% helix, 3% strand | P29396 |
| X, Y | 50S ribosomal protein L7/L12 | protein | 29 | 79% helix, 3% strand | P29396 |
| Z | 50S ribosomal protein L7/L12 | protein | 27 | 74% helix, 4% strand | P29396 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 106 | 0.42 | 0.77 | 12 | empty |
Interfaces
15 interfaces between chains.
- W–X · 801 Ų buried · 1 hydrogen bond · protein-protein
- U–V · 778 Ų buried · 2 hydrogen bonds · protein-protein
- A–V · 726 Ų buried · 7 hydrogen bonds · protein-protein
- Y–Z · 689 Ų buried · 2 hydrogen bonds · protein-protein
- A–Y · 451 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1ZAV · Ribosomal Protein L10-L12(NTD) Complex, Space Group P21 · the same entry in another collection · chain Y against Y, TM-score 1.00
- P29396 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L7/L12 (P29396) · a predicted model of the same protein · chain X against A, TM-score 0.85
- P29394 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L10 (P29394) · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29394
- Every structure of UniProt P29396
- Elsewhere: RCSB PDB 1ZAV · PDBe 1ZAV · UniProt P29394 · UniProt P29396
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