MolNFT v1 · #29343 · protein
Crystal structure of human gamma-tubulin bound to gtpgammas
1Z5V · Tubulin gamma-1 chain: “Crystal structure of human gamma-tubulin bound to gtpgammas”. X-ray diffraction, 2 ligands (GSP, MG), 6 pockets (best druggability 0.54). MolNFT v1 #29343 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1Z5V
- Type
- protein
- Length
- 412 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tubulin gamma-1 chain
- UniProt
- P23258
- Ligands
- GSP, MG
- Pockets
- 6 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tubulin gamma-1 chain | protein | 412 | 42% helix, 18% strand | P23258 |
Ligands and binding sites
- GSP · 5'-guanosine-diphosphate-monothiophosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.54 | 0.88 | 18 | empty |
| 2 | 187 | 0.52 | 0.78 | 36 | MG, GSP |
| 3 | 164 | 0.47 | 0.76 | 28 | empty |
| 4 | 66 | 0.33 | 0.76 | 15 | empty |
| 5 | 70 | 0.33 | 0.75 | 17 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23258
- Elsewhere: RCSB PDB 1Z5V · PDBe 1Z5V · UniProt P23258
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