MolNFT v1 · #28786 · protein
Human steroidogenic factor 1 lbd with bound co-factor peptide
1YOW: “Human steroidogenic factor 1 lbd with bound co-factor peptide”. X-ray diffraction, 1 ligand (P0E), 4 pockets (best druggability 0.83). MolNFT v1 #28786 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1YOW
- Type
- protein
- Length
- 241 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Steroidogenic factor 1; TIF2 peptide
- UniProt
- Q13285
- Ligands
- P0E
- Pockets
- 4 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Steroidogenic factor 1 | protein | 230 | 74% helix, 3% strand | Q13285 |
| B | TIF2 peptide | protein | 11 | 64% helix, 0% strand | — |
Ligands and binding sites
- P0E · Phosphatidyl ethanol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 523 | 0.83 | 0.88 | 36 | P0E |
| 2 | 238 | 0.66 | 0.83 | 35 | empty |
| 3 | 76 | 0.33 | 0.75 | 13 | empty |
| 4 | 67 | 0.32 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 367 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13285
- Elsewhere: RCSB PDB 1YOW · PDBe 1YOW · UniProt Q13285
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