MolNFT v1 · #28600 · protein

Initial structural analysis of plasmodium falciparum glycerol-3- phosphate dehydrogenase

1YJ8 · Glycerol-3-phosphate dehydrogenase: “Initial structural analysis of plasmodium falciparum glycerol-3- phosphate dehydrogenase”. X-ray diffraction, 8 pockets (best druggability 0.74). MolNFT v1 #28600 on GenesisL1: 3D structure…

PDB: 1YJ8
Type: protein
Length: 1,071 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glycerol-3-phosphate dehydrogenase
EC: 1.1.1.8
UniProt: Q8I5P5
Pockets: 8 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Glycerol-3-phosphate dehydrogenase (EC 1.1.1.8)	protein	357	52% helix, 13% strand	Q8I5P5

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	765	0.74	0.79	50	empty
2	836	0.73	0.77	55	empty
3	745	0.72	0.78	42	empty
4	285	0.55	0.76	25	empty
5	284	0.54	0.76	29	empty

Interfaces

2 interfaces between chains.

B–C · 2279 Å² buried · 42 hydrogen bonds · protein-protein
A–B · 470 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

1YJ8 · Initial structural analysis of Plasmodium falciparum Glycerol-3-phosphate dehydrogenase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8I5P5
Elsewhere: RCSB PDB 1YJ8 · PDBe 1YJ8 · UniProt Q8I5P5

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