MolNFT v1 · #28484 · protein

Recombinant yeast fumarase

1YFM: “Recombinant yeast fumarase”. X-ray diffraction, 4 pockets (best druggability 0.40). MolNFT v1 #28484 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1YFM
Type: protein
Length: 450 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fumarase
EC: 4.2.1.2
UniProt: P08417
Pockets: 4 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 63% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fumarase (EC 4.2.1.2)	protein	450	63% helix, 7% strand	P08417

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.40	0.82	15	empty
2	105	0.40	0.76	18	empty
3	94	0.34	0.74	19	empty
4	55	0.31	0.76	13	empty

Compared structures

1YFM · Recombinant yeast fumarase · the same entry in another collection · chain A against A, TM-score 1.00
P08417 · AlphaFold monomer V2.0 prediction for fumarate hydratase, mitochondrial (P08417) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08417
Elsewhere: RCSB PDB 1YFM · PDBe 1YFM · UniProt P08417

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