MolNFT v1 · #28311 · protein

Structure of tena from bacillus subtilis

1YAF · Transcriptional activator tena: “Structure of tena from bacillus subtilis”. X-ray diffraction, 12 pockets (best druggability 0.77). MolNFT v1 #28311 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1YAF
Type: protein
Length: 874 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional activator tena
UniProt: P25052
Pockets: 12 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Transcriptional activator tena	protein	219	78% helix, 0% strand	P25052
C, D	Transcriptional activator tena	protein	218	77% helix, 0% strand	P25052

Pockets

12 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	248	0.77	0.90	36	empty
2	924	0.77	0.79	91	empty
3	764	0.75	0.79	69	empty
4	316	0.74	0.85	47	empty
5	172	0.71	0.88	29	empty

Interfaces

6 interfaces between chains.

A–D · 1080 Å² buried · 21 hydrogen bonds · protein-protein
B–C · 1059 Å² buried · 18 hydrogen bonds · protein-protein
A–C · 911 Å² buried · 7 hydrogen bonds · protein-protein
B–D · 909 Å² buried · 6 hydrogen bonds · protein-protein
C–D · 168 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1YAF · Structure of TenA from Bacillus subtilis · the same entry in another collection · chain A against A, TM-score 1.00
P25052 · AlphaFold monomer V2.0 prediction for aminopyrimidine aminohydrolase (P25052) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25052
Elsewhere: RCSB PDB 1YAF · PDBe 1YAF · UniProt P25052

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.