MolNFT v1 · #28245 · protein

Solution NMR-derived global fold of malate synthase G from E.COLI

1Y8B: “Solution NMR-derived global fold of malate synthase G from E.COLI”. Solution nmr, 18 pockets (best druggability 0.88). MolNFT v1 #28245 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1Y8B
Type: protein
Length: 723 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Malate synthase G
EC: 2.3.3.9
UniProt: P37330
Pockets: 18 · best druggability 0.88

Structure

solution nmr · 1 distinct chain · 44% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Malate synthase G (EC 2.3.3.9)	protein	723	44% helix, 9% strand	P37330

Pockets

18 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	999	0.88	0.89	133	empty
2	140	0.80	0.96	24	empty
3	77	0.75	0.97	26	empty
4	52	0.70	0.98	25	empty
5	53	0.69	0.97	17	empty

Compared structures

1Y8B · Solution NMR-Derived Global Fold of Malate Synthase G from E.coli · the same entry in another collection · chain A against A, TM-score 1.00
P37330 · AlphaFold monomer V2.0 prediction for malate synthase G (P37330) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37330
Elsewhere: RCSB PDB 1Y8B · PDBe 1Y8B · UniProt P37330

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