MolNFT v1 · #28226 · protein

Mammalian scan domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain

1Y7Q · Zinc finger protein 174: “Mammalian scan domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain”. Solution nmr, 3 pockets (best druggability 0.55). MolNFT v1 #28226 on GenesisL1: 3D structure, binding sites…

PDB: 1Y7Q
Type: protein
Length: 196 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Zinc finger protein 174
UniProt: Q15697
Pockets: 3 · best druggability 0.55

Structure

solution nmr · 1 distinct chain · 58% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Zinc finger protein 174	protein	98	58% helix, 0% strand	Q15697

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	271	0.55	0.76	27	empty
2	68	0.39	0.79	17	empty
3	51	0.25	0.72	14	empty

Interfaces

1 interface between chains.

A–B · 1542 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

1Y7Q · Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal… · the same entry in another collection · chain A against A, TM-score 1.00
Q15697 · AlphaFold monomer V2.0 prediction for zinc finger protein 174 (Q15697) · a predicted model of the same protein · chain A against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15697
Elsewhere: RCSB PDB 1Y7Q · PDBe 1Y7Q · UniProt Q15697

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