MolNFT v1 · #28205 · protein
Solution structure of mlin-2/MLIN-7 L27 domain complex
1Y74 · Lin 7 homolog B: “Solution structure of mlin-2/MLIN-7 L27 domain complex”. Solution nmr, 1 pocket (best druggability 0.29). MolNFT v1 #28205 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1Y74
- Type
- protein
- Length
- 214 residues
- Chains
- 4
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lin 7 homolog B; Peripheral plasma membrane protein cask
- EC
- 2.7.1.-
- UniProt
- O88951, O70589
- Pockets
- 1 · best druggability 0.29
Structure
solution nmr · 2 distinct chains · 84% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Lin 7 homolog B | protein | 57 | 86% helix, 0% strand | O88951 |
| B, D | Peripheral plasma membrane protein cask (EC 2.7.1.-) | protein | 50 | 82% helix, 0% strand | O70589 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.29 | 0.73 | 13 | empty |
Interfaces
6 interfaces between chains.
- A–D · 1259 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 1180 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 448 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 243 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 221 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1Y74 · Solution Structure of mLin-2/mLin-7 L27 Domain Complex · the same entry in another collection · chain A against A, TM-score 1.00
- O70589 · AlphaFold monomer V2.0 prediction for peripheral plasma membrane protein cask (O70589) · a predicted model of the same protein · chain B against A, TM-score 0.81
- O88951 · AlphaFold monomer V2.0 prediction for protein lin-7 homolog B (O88951) · a predicted model of the same protein · chain A against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O88951
- Every structure of UniProt O70589
- Elsewhere: RCSB PDB 1Y74 · PDBe 1Y74 · UniProt O88951 · UniProt O70589
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