MolNFT v1 · #28175 · protein

Crystal structure of beta-hexosaminidase from vibrio cholerae in complex with N-acetyl-D-glucosamine to a resolution of 1.85

1Y65: “Crystal structure of beta-hexosaminidase from vibrio cholerae in complex with N-acetyl-D-glucosamine to a…”. X-ray diffraction, 1 ligand (NAG), 1 pocket (best druggability 0.58). MolNFT v1 #28175 on GenesisL1: 3D structure, binding…

PDB: 1Y65
Type: protein
Length: 330 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-hexosaminidase
EC: 3.2.1.52
UniProt: Q9KU37
Ligands: NAG
Pockets: 1 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-hexosaminidase (EC 3.2.1.52)	protein	330	45% helix, 13% strand	Q9KU37

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	249	0.58	0.78	30	NAG

Compared structures

1Y65 · Crystal structure of beta-hexosaminidase from Vibrio cholerae in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Q9KU37 · AlphaFold monomer V2.0 prediction for beta-hexosaminidase (Q9KU37) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9KU37
Elsewhere: RCSB PDB 1Y65 · PDBe 1Y65 · UniProt Q9KU37

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