MolNFT v1 · #28157 · protein

Crystal structure of truncated se-met hypoxic response protein I (hrpi)

1Y5H · Hypothetical protein RV2626C: “Crystal structure of truncated se-met hypoxic response protein I (hrpi)”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #28157 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1Y5H
Type: protein
Length: 245 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypothetical protein RV2626C
UniProt: O06186
Pockets: 1 · best druggability 0.33

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hypothetical protein RV2626C	protein	123	41% helix, 27% strand	O06186
B	Hypothetical protein RV2626C	protein	122	39% helix, 26% strand	O06186

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.33	0.77	13	empty

Interfaces

1 interface between chains.

A–B · 739 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 modified, 2 disulfide (engineered, disulfide).

Compared structures

1Y5H · Crystal structure of truncated Se-Met Hypoxic Response Protein I (HRPI) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O06186
Elsewhere: RCSB PDB 1Y5H · PDBe 1Y5H · UniProt O06186

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