MolNFT v1 · #2809 · protein
Michaelis complex of fructose-2,6-bisphosphatase
1C81: “Michaelis complex of fructose-2,6-bisphosphatase”. X-ray diffraction, 1 ligand (FDQ), 1 pocket (best druggability 0.62). MolNFT v1 #2809 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1C81
- Type
- protein
- Length
- 191 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructose-2,6-bisphosphatase
- EC
- 3.1.3.46
- UniProt
- P07953
- Ligands
- FDQ
- Pockets
- 1 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fructose-2,6-bisphosphatase (EC 3.1.3.46) | protein | 191 | 41% helix, 16% strand | P07953 |
Ligands and binding sites
- FDQ · 2,5-anhydro-1-deoxy-1-phosphono-6-O-phosphono-D-glucitol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 268 | 0.62 | 0.80 | 35 | FDQ |
Compared structures
- 1C81 · Michaelis complex of fructose-2,6-bisphosphatase · the same entry in another collection · chain A against A, TM-score 1.00
- P07953 · AlphaFold monomer V2.0 prediction for 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-bisphosphatase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07953
- Elsewhere: RCSB PDB 1C81 · PDBe 1C81 · UniProt P07953
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