MolNFT v1 · #28042 · protein

Structure of unphosphorylated STAT5A

1Y1U · Signal transducer and activator of transcription 5A: “Structure of unphosphorylated STAT5A”. X-ray diffraction, 20 pockets (best druggability 0.77). MolNFT v1 #28042 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1Y1U
Type: protein
Length: 1,632 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Signal transducer and activator of transcription 5A
UniProt: P42230
Pockets: 20 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Signal transducer and activator of transcription 5A	protein	544	49% helix, 16% strand	P42230

Pockets

20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	826	0.77	0.81	76	empty
2	408	0.66	0.79	32	empty
3	407	0.66	0.79	32	empty
4	419	0.65	0.78	37	empty
5	142	0.57	0.83	27	empty

Interfaces

2 interfaces between chains.

A–B · 1580 Å² buried · 26 hydrogen bonds · protein-protein
A–C · 499 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1Y1U · Structure of unphosphorylated STAT5a · the same entry in another collection · chain A against A, TM-score 1.00
P42230 · AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription 5A… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42230
Elsewhere: RCSB PDB 1Y1U · PDBe 1Y1U · UniProt P42230

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