MolNFT v1 · #27938 · protein

NMR structure of the pig prion protein

1XYQ · Major prion protein: “NMR structure of the pig prion protein”. Solution nmr, 1 pocket (best druggability 0.38). MolNFT v1 #27938 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XYQ
Type: protein
Length: 111 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Major prion protein
UniProt: P49927
Pockets: 1 · best druggability 0.38

Structure

solution nmr · 1 distinct chain · 50% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Major prion protein	protein	111	50% helix, 4% strand	P49927

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	93	0.38	0.76	11	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1XYQ · NMR structure of the pig prion protein · the same entry in another collection · chain A against A, TM-score 1.00
P49927 · AlphaFold monomer V2.0 prediction for major prion protein (P49927) · a predicted model of the same protein · chain A against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49927
Elsewhere: RCSB PDB 1XYQ · PDBe 1XYQ · UniProt P49927

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