MolNFT v1 · #27932 · protein

NMR structure of the canine prion protein

1XYK: “NMR structure of the canine prion protein”. Solution nmr, 2 pockets (best druggability 0.53). MolNFT v1 #27932 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XYK
Type: protein
Length: 111 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prion protein
UniProt: O46501
Pockets: 2 · best druggability 0.53

Structure

solution nmr · 1 distinct chain · 52% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prion protein	protein	111	52% helix, 0% strand	O46501

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.53	0.83	27	empty
2	50	0.37	0.80	15	empty

Compared structures

1XYK · NMR Structure of the canine prion protein · the same entry in another collection · chain A against A, TM-score 1.00
O46501 · AlphaFold monomer V2.0 prediction for major prion protein (O46501) · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O46501
Elsewhere: RCSB PDB 1XYK · PDBe 1XYK · UniProt O46501

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.