MolNFT v1 · #27868 · protein

Crystal structrue of goose delta crystallin

1XWO: “Crystal structrue of goose delta crystallin”. X-ray diffraction, 20 pockets (best druggability 0.78). MolNFT v1 #27868 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XWO
Type: protein
Length: 1,794 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Delta crystallin
EC: 4.3.2.1
UniProt: P33110
Pockets: 20 · best druggability 0.78

Structure

x-ray diffraction · 4 distinct chains · 67% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Delta crystallin (EC 4.3.2.1)	protein	448	67% helix, 5% strand	P33110
B	Delta crystallin (EC 4.3.2.1)	protein	448	66% helix, 5% strand	P33110
C	Delta crystallin (EC 4.3.2.1)	protein	449	68% helix, 4% strand	P33110
D	Delta crystallin (EC 4.3.2.1)	protein	449	67% helix, 5% strand	P33110

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	829	0.78	0.81	59	empty
2	790	0.78	0.82	63	empty
3	754	0.77	0.82	57	empty
4	816	0.77	0.81	62	empty
5	75	0.76	0.99	18	empty

Interfaces

6 interfaces between chains.

B–D · 3829 Å² buried · 76 hydrogen bonds · protein-protein
A–C · 3739 Å² buried · 67 hydrogen bonds · protein-protein
B–C · 1917 Å² buried · 27 hydrogen bonds · protein-protein
A–D · 1859 Å² buried · 24 hydrogen bonds · protein-protein
A–B · 1824 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

1XWO · crystal structrue of goose delta crystallin · the same entry in another collection · chain D against D, TM-score 1.00
P33110 · AlphaFold monomer V2.0 prediction for argininosuccinate lyase (P33110) · a predicted model of the same protein · chain D against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P33110
Elsewhere: RCSB PDB 1XWO · PDBe 1XWO · UniProt P33110

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.