MolNFT v1 · #2782 · protein

Staphylokinase (sak) dimer

1C77: “Staphylokinase (sak) dimer”. X-ray diffraction, 2 pockets (best druggability 0.51). MolNFT v1 #2782 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1C77
Type: protein
Length: 258 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Staphylokinase
EC: 3.4.24.29
UniProt: P68802
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Staphylokinase (EC 3.4.24.29)	protein	130	9% helix, 37% strand	P68802
B	Staphylokinase (EC 3.4.24.29)	protein	128	9% helix, 46% strand	P68802

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	228	0.51	0.76	37	empty
2	72	0.35	0.76	19	empty

Interfaces

1 interface between chains.

A–B · 570 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

1C77 · Staphylokinase (sak) dimer · the same entry in another collection · chain A against A, TM-score 1.00
P68802 · AlphaFold monomer V2.0 prediction for staphylokinase (P68802) · a predicted model of the same protein · chain B against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P68802
Elsewhere: RCSB PDB 1C77 · PDBe 1C77 · UniProt P68802

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