MolNFT v1 · #27753 · protein
Urate oxidase from aspergillus flavus complexed with guanine
1XT4 · Uricase: “Urate oxidase from aspergillus flavus complexed with guanine”. X-ray diffraction, 1 ligand (GUN), 2 pockets (best druggability 0.56). MolNFT v1 #27753 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1XT4
- Type
- protein
- Length
- 295 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uricase
- EC
- 1.7.3.3
- UniProt
- Q00511
- Ligands
- GUN
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uricase (EC 1.7.3.3) | protein | 295 | 27% helix, 39% strand | Q00511 |
Ligands and binding sites
- GUN · Guanine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 216 | 0.56 | 0.78 | 22 | empty |
| 2 | 185 | 0.47 | 0.75 | 21 | GUN |
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 1XT4 · Urate Oxidase From Aspergillus Flavus Complexed With Guanine · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00511
- Elsewhere: RCSB PDB 1XT4 · PDBe 1XT4 · UniProt Q00511
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