MolNFT v1 · #27750 · protein
The structure of ralf
1XSZ · Guanine nucleotide exchange protein: “The structure of ralf”. X-ray diffraction, 9 pockets (best druggability 0.74). MolNFT v1 #27750 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1XSZ
- Type
- protein
- Length
- 712 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide exchange protein
- UniProt
- Q8RT31
- Pockets
- 9 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Guanine nucleotide exchange protein | protein | 356 | 52% helix, 11% strand | Q8RT31 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 476 | 0.74 | 0.83 | 59 | empty |
| 2 | 368 | 0.66 | 0.80 | 45 | empty |
| 3 | 224 | 0.64 | 0.83 | 26 | empty |
| 4 | 104 | 0.52 | 0.82 | 28 | empty |
| 5 | 174 | 0.50 | 0.78 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 739 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 1XSZ · The structure of RalF · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8RT31
- Elsewhere: RCSB PDB 1XSZ · PDBe 1XSZ · UniProt Q8RT31
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