MolNFT v1 · #27712 · DNA

Solution structure of a platinum-acridine modified octamer

1XRW · 5'-D(*CP*CP*TP*CP*GP*TP*CP*C)-3': “Solution structure of a platinum-acridine modified octamer”. Solution nmr, 1 ligand (2PT). MolNFT v1 #27712 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XRW
Type: DNA
Length: 16 nucleotides
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*CP*CP*TP*CP*GP*TP*CP*C)-3'; 5'-D(*GP*GP*AP*CP*GP*AP*GP*G)-3'
Ligands: 2PT

Structure

solution nmr · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5'-D(CPCPTPCPGPTPCPC)-3'	dna	8	—	—
B	5'-D(GPGPAPCPGPAPGPG)-3'	dna	8	—	—

Ligands and binding sites

2PT · 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea-platinum(ii)-ethane-1,2-diamine · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 361 Å² buried · 40 hydrogen bonds · nucleic-nucleic

Compared structures

1XRW · Solution Structure of a Platinum-Acridine Modified Octamer · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1XRW · PDBe 1XRW

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