MolNFT v1 · #27610 · protein

Solution structure of human survivin

1XOX · Apoptosis inhibitor survivin: “Solution structure of human survivin”. Solution nmr, 1 ligand (ZN), 2 pockets (best druggability 0.59). MolNFT v1 #27610 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XOX
Type: protein
Length: 234 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apoptosis inhibitor survivin
UniProt: O15392
Ligands: ZN
Pockets: 2 · best druggability 0.59

Structure

solution nmr · 1 distinct chain · 32% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Apoptosis inhibitor survivin	protein	117	32% helix, 8% strand	O15392

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	168	0.59	0.82	25	empty
2	120	0.58	0.84	17	empty

Interfaces

1 interface between chains.

A–B · 511 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

1XOX · Solution structure of human survivin · the same entry in another collection · chain A against A, TM-score 1.00
O15392 · AlphaFold monomer V2.0 prediction for baculoviral iap repeat- containing protein 5… · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15392
Elsewhere: RCSB PDB 1XOX · PDBe 1XOX · UniProt O15392

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