MolNFT v1 · #27565 · protein

Crystal structure of E.COLI tpr-protein nlpi

1XNF · Lipoprotein nlpi: “Crystal structure of E.COLI tpr-protein nlpi”. X-ray diffraction, 7 pockets (best druggability 0.58). MolNFT v1 #27565 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XNF
Type: protein
Length: 521 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipoprotein nlpi
UniProt: P39833
Pockets: 7 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lipoprotein nlpi	protein	259	76% helix, 0% strand	P39833
B	Lipoprotein nlpi	protein	262	74% helix, 0% strand	P39833

Ligands and binding sites

TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	148	0.58	0.83	28	empty
2	166	0.48	0.77	21	TRS
3	170	0.48	0.76	25	TRS
4	228	0.47	0.73	26	empty
5	129	0.41	0.75	21	empty

Interfaces

1 interface between chains.

A–B · 1648 Å² buried · 26 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

1XNF · Crystal structure of E.coli TPR-protein NlpI · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P39833
Elsewhere: RCSB PDB 1XNF · PDBe 1XNF · UniProt P39833

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.