MolNFT v1 · #27524 · protein

Structure of the armadillo repeat domain of plakophilin 1

1XM9: “Structure of the armadillo repeat domain of plakophilin 1”. X-ray diffraction, 2 pockets (best druggability 0.60). MolNFT v1 #27524 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XM9
Type: protein
Length: 420 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plakophilin 1
UniProt: Q13835
Pockets: 2 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Plakophilin 1	protein	420	70% helix, 0% strand	Q13835

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.60	0.90	26	empty
2	65	0.29	0.74	23	empty

Compared structures

1XM9 · Structure of the armadillo repeat domain of plakophilin 1 · the same entry in another collection · chain A against A, TM-score 1.00
Q13835 · AlphaFold monomer V2.0 prediction for plakophilin-1 (Q13835) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13835
Elsewhere: RCSB PDB 1XM9 · PDBe 1XM9 · UniProt Q13835

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