MolNFT v1 · #27459 · protein
Crystal structure of hypoxic response protein I (hrpi) with two coordinated zinc ions
1XKF · Hypothetical protein RV2626C: “Crystal structure of hypoxic response protein I (hrpi) with two coordinated zinc ions”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.65). MolNFT v1 #27459 on GenesisL1: 3D…
- PDB
- 1XKF
- Type
- protein
- Length
- 243 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein RV2626C
- UniProt
- O06186
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical protein RV2626C | protein | 120 | 42% helix, 28% strand | O06186 |
| B | Hypothetical protein RV2626C | protein | 123 | 41% helix, 28% strand | O06186 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 387 | 0.65 | 0.79 | 51 | empty |
| 2 | 105 | 0.42 | 0.78 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 668 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1XKF · Crystal structure of Hypoxic Response Protein I (HRPI) with two coordinated zinc ions · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O06186
- Elsewhere: RCSB PDB 1XKF · PDBe 1XKF · UniProt O06186
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.