MolNFT v1 · #27450 · protein

Crystal structure of the M3G-cap-binding domain of SNURPORTIN1 in complex with a M3GPPPG-cap dinucleotide

1XK5 · Snurportin-1: “Crystal structure of the M3G-cap-binding domain of SNURPORTIN1 in complex with a M3GPPPG-cap dinucleotide”. X-ray diffraction, 1 ligand (TPG), 2 pockets (best druggability 0.38). MolNFT v1 #27450 on GenesisL1: 3D…

PDB: 1XK5
Type: protein
Length: 204 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Snurportin-1
UniProt: O95149
Ligands: TPG
Pockets: 2 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 18% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Snurportin-1	protein	204	18% helix, 37% strand	O95149

Ligands and binding sites

TPG · 2,2,7-trimethyl-guanosine-5'-triphosphate-5'-guanosine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.38	0.77	17	empty
2	69	0.36	0.77	19	empty

Compared structures

1XK5 · Crystal structure of the m3G-cap-binding domain of snurportin1 in complex with a… · the same entry in another collection · chain A against A, TM-score 1.00
O95149 · AlphaFold monomer V2.0 prediction for snurportin-1 (O95149) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95149
Elsewhere: RCSB PDB 1XK5 · PDBe 1XK5 · UniProt O95149

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