MolNFT v1 · #27444 · protein
Crystal structures of the G139A, G139A-no and G143H mutants of human heme oxygenase-1
1XJZ · Heme oxygenase 1: “Crystal structures of the G139A, G139A-no and G143H mutants of human heme oxygenase-1”. X-ray diffraction, 1 ligand (HEM), 2 pockets (best druggability 0.73). MolNFT v1 #27444 on GenesisL1: 3D structure, binding…
- PDB
- 1XJZ
- Type
- protein
- Length
- 428 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heme oxygenase 1
- EC
- 1.14.99.3
- UniProt
- P09601
- Ligands
- HEM
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Heme oxygenase 1 (EC 1.14.99.3) | protein | 214 | 75% helix, 0% strand | P09601 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 369 | 0.73 | 0.84 | 40 | HEM |
| 2 | 404 | 0.72 | 0.83 | 40 | HEM |
Compared structures
- 1XJZ · Crystal Structures of the G139A, G139A-NO and G143H Mutants of Human Heme Oxygenase-1 · the same entry in another collection · chain A against A, TM-score 1.00
- P09601 · AlphaFold monomer V2.0 prediction for heme oxygenase 1 (P09601) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09601
- Elsewhere: RCSB PDB 1XJZ · PDBe 1XJZ · UniProt P09601
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