MolNFT v1 · #27362 · protein
Crystal structure of a 40 kda signalling protein from porcine (spp-40) at 2.89A resolution
1XHG: “Crystal structure of a 40 kda signalling protein from porcine (spp-40) at 2.89A resolution”. X-ray diffraction, 1 ligand (NAG), 4 pockets (best druggability 0.56). MolNFT v1 #27362 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1XHG
- Type
- protein
- Length
- 361 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spp-40
- UniProt
- Q29411
- Ligands
- NAG
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spp-40 | protein | 361 | 36% helix, 23% strand | Q29411 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 193 | 0.56 | 0.80 | 24 | empty |
| 2 | 177 | 0.54 | 0.79 | 22 | empty |
| 3 | 107 | 0.38 | 0.75 | 19 | empty |
| 4 | 50 | 0.29 | 0.75 | 15 | empty |
Modifications
Observed in the structure: 2 disulfide, 1 glycan (disulfide, N-glycosylation).
Compared structures
- 1XHG · Crystal structure of a 40 kDa signalling protein from Porcine (SPP-40) at 2.89A resolution · the same entry in another collection · chain A against A, TM-score 1.00
- Q29411 · AlphaFold monomer V2.0 prediction for chitinase-3-like protein 1 (Q29411) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q29411
- Elsewhere: RCSB PDB 1XHG · PDBe 1XHG · UniProt Q29411
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