MolNFT v1 · #27321 · protein

Conserved hypothetical protein pfu-877259-001 from pyrococcus furiosus

1XG7: “Conserved hypothetical protein pfu-877259-001 from pyrococcus furiosus”. X-ray diffraction, 3 pockets (best druggability 0.70). MolNFT v1 #27321 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XG7
Type: protein
Length: 484 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypothetical protein
UniProt: Q8U2D5
Pockets: 3 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 68% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hypothetical protein	protein	245	67% helix, 0% strand	Q8U2D5
B	Hypothetical protein	protein	239	69% helix, 0% strand	Q8U2D5

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	398	0.70	0.82	36	empty
2	397	0.69	0.81	41	empty
3	92	0.38	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 1094 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1XG7 · Conserved hypothetical protein Pfu-877259-001 from Pyrococcus furiosus · the same entry in another collection · chain A against A, TM-score 1.00
Q8U2D5 · AlphaFold monomer V2.0 prediction for N-GLYCOSYLASE/DNA lyase (Q8U2D5) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8U2D5
Elsewhere: RCSB PDB 1XG7 · PDBe 1XG7 · UniProt Q8U2D5

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