MolNFT v1 · #27242 · protein
NAD+-dependent (R)-2-hydroxyglutarate dehydrogenase from acidaminococcus fermentans
1XDW: “NAD+-dependent (R)-2-hydroxyglutarate dehydrogenase from acidaminococcus fermentans”. X-ray diffraction, 3 pockets (best druggability 0.71). MolNFT v1 #27242 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1XDW
- Type
- protein
- Length
- 331 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NAD+-dependent (R)-2-hydroxyglutarate dehydrogenase
- EC
- 1.1.1.-
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NAD+-dependent (R)-2-hydroxyglutarate dehydrogenase (EC 1.1.1.-) | protein | 331 | 38% helix, 16% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 585 | 0.71 | 0.79 | 54 | empty |
| 2 | 67 | 0.43 | 0.82 | 21 | empty |
| 3 | 118 | 0.42 | 0.76 | 20 | empty |
Compared structures
- 1XDW · NAD+-dependent (R)-2-Hydroxyglutarate Dehydrogenase from Acidaminococcus fermentans · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1XDW · PDBe 1XDW
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