MolNFT v1 · #2718 · protein

Decarboxylase catalytic antibody 21D8 unliganded form

1C5B · Chimeric decarboxylase antibody 21D8: “Decarboxylase catalytic antibody 21D8 unliganded form”. X-ray diffraction, 3 pockets (best druggability 0.59). MolNFT v1 #2718 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1C5B
Type: protein
Length: 429 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chimeric decarboxylase antibody 21D8
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Chimeric decarboxylase antibody 21D8	protein	214	6% helix, 51% strand	—
H	Chimeric decarboxylase antibody 21D8	protein	215	9% helix, 50% strand	—

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	142	0.59	0.83	21	empty
2	310	0.54	0.75	32	empty
3	53	0.28	0.75	16	empty

Interfaces

1 interface between chains.

L–H · 1868 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1C5B · Decarboxylase catalytic antibody 21D8 unliganded form · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1C5B · PDBe 1C5B

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