MolNFT v1 · #27122 · protein

Crystal structure of the human BETA2-chimaerin

1XA6: “Crystal structure of the human BETA2-chimaerin”. X-ray diffraction, 1 ligand (ZN), 4 pockets (best druggability 0.73). MolNFT v1 #27122 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XA6
Type: protein
Length: 399 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BETA2-chimaerin
UniProt: P52757
Ligands: ZN
Pockets: 4 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BETA2-chimaerin	protein	399	36% helix, 8% strand	P52757

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	584	0.73	0.80	78	empty
2	58	0.54	0.88	16	empty
3	160	0.47	0.77	23	empty
4	99	0.38	0.75	21	empty

Compared structures

1XA6 · Crystal Structure of the Human Beta2-Chimaerin · the same entry in another collection · chain A against A, TM-score 1.00
P52757 · AlphaFold monomer V2.0 prediction for beta-chimaerin (P52757) · a predicted model of the same protein · chain A against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52757
Elsewhere: RCSB PDB 1XA6 · PDBe 1XA6 · UniProt P52757

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.