MolNFT v1 · #27049 · protein
Crystal structure of phosphoglucose isomerase from pyrococcus furiosus with bound 5-phospho-D-arabinonate
1X82 · Glucose-6-phosphate isomerase: “Crystal structure of phosphoglucose isomerase from pyrococcus furiosus with bound 5-phospho-D-arabinonate”. X-ray diffraction, 1 ligand (PA5), 2 pockets (best druggability 0.65). MolNFT v1 #27049 on…
- PDB
- 1X82
- Type
- protein
- Length
- 190 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose-6-phosphate isomerase
- EC
- 5.3.1.9
- UniProt
- P83194
- Ligands
- PA5
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucose-6-phosphate isomerase (EC 5.3.1.9) | protein | 190 | 11% helix, 42% strand | P83194 |
Ligands and binding sites
- PA5 · 5-phosphoarabinonic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 158 | 0.65 | 0.86 | 23 | PA5 |
| 2 | 62 | 0.40 | 0.81 | 22 | empty |
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
- 1X82 · CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE FROM PYROCOCCUS FURIOSUS WITH BOUND… · the same entry in another collection · chain A against A, TM-score 1.00
- P83194 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate isomerase (P83194) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P83194
- Elsewhere: RCSB PDB 1X82 · PDBe 1X82 · UniProt P83194
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