MolNFT v1 · #26804 · protein

Solution structure of the carboxyl-terminal rgc domain in human IQGAP1

1X0H · RAS GTPase-activating-like protein IQGAP1: “Solution structure of the carboxyl-terminal rgc domain in human IQGAP1”. Solution nmr, 2 pockets (best druggability 0.76). MolNFT v1 #26804 on GenesisL1: 3D structure, binding sites and…

PDB: 1X0H
Type: protein
Length: 112 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RAS GTPase-activating-like protein IQGAP1
UniProt: P46940
Pockets: 2 · best druggability 0.76

Structure

solution nmr · 1 distinct chain · 29% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RAS GTPase-activating-like protein IQGAP1	protein	112	29% helix, 27% strand	P46940

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.76	0.96	22	empty
2	114	0.45	0.77	20	empty

Compared structures

1X0H · Solution structure of the carboxyl-terminal RGC domain in human IQGAP1 · the same entry in another collection · chain A against A, TM-score 1.00
P46940 · AlphaFold monomer V2.0 prediction for RAS GTPase-activating-like protein IQGAP1 (P46940) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46940
Elsewhere: RCSB PDB 1X0H · PDBe 1X0H · UniProt P46940

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