MolNFT v1 · #26708 · protein

E.COLI NAD synthetase

1WXF · NH(3)-dependent NAD(+) synthetase: “E.COLI NAD synthetase”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #26708 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1WXF
Type: protein
Length: 255 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NH(3)-dependent NAD(+) synthetase
EC: 6.3.1.5
UniProt: P18843
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NH(3)-dependent NAD(+) synthetase (EC 6.3.1.5)	protein	255	54% helix, 9% strand	P18843

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	223	0.52	0.77	35	empty
2	79	0.35	0.76	18	empty

Compared structures

1WXF · E.coli NAD Synthetase · the same entry in another collection · chain A against A, TM-score 1.00
P18843 · AlphaFold monomer V2.0 prediction for NH(3)-dependent NAD(+) synthetase (P18843) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P18843
Elsewhere: RCSB PDB 1WXF · PDBe 1WXF · UniProt P18843

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