MolNFT v1 · #26705 · protein

Crystal structure of the copper-free streptomyces castaneoglobisporus tyrosinase complexed with a caddie protein

1WXC: “Crystal structure of the copper-free streptomyces castaneoglobisporus tyrosinase complexed with a caddie…”. X-ray diffraction, 1 ligand (NO3), 2 pockets (best druggability 0.44). MolNFT v1 #26705 on GenesisL1: 3D structure, binding…

PDB: 1WXC
Type: protein
Length: 345 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosinase; Melc
EC: 1.14.18.1
UniProt: Q83WS2, Q83WS1
Ligands: NO3
Pockets: 2 · best druggability 0.44

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosinase (EC 1.14.18.1)	protein	273	41% helix, 4% strand	Q83WS2
B	Melc	protein	72	17% helix, 39% strand	Q83WS1

Ligands and binding sites

NO3 · Nitrate ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	114	0.44	0.78	26	empty
2	52	0.25	0.73	13	empty

Interfaces

1 interface between chains.

A–B · 1018 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

1WXC · Crystal Structure of the copper-free Streptomyces castaneoglobisporus tyrosinase… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q83WS2
Every structure of UniProt Q83WS1
Elsewhere: RCSB PDB 1WXC · PDBe 1WXC · UniProt Q83WS2 · UniProt Q83WS1

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