MolNFT v1 · #26694 · protein

Crystal structure of transaldolase from thermus thermophilus HB8

1WX0: “Crystal structure of transaldolase from thermus thermophilus HB8”. X-ray diffraction, 20 pockets (best druggability 0.67). MolNFT v1 #26694 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1WX0
Type: protein
Length: 2,110 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transaldolase
EC: 2.2.1.2
UniProt: Q5SJE8
Pockets: 20 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J	Transaldolase (EC 2.2.1.2)	protein	211	54% helix, 18% strand	Q5SJE8

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	290	0.67	0.83	40	empty
2	231	0.63	0.82	36	empty
3	155	0.62	0.85	23	empty
4	94	0.61	0.88	21	empty
5	240	0.60	0.80	34	empty

Interfaces

25 interfaces between chains.

A–E · 1270 Å² buried · 18 hydrogen bonds · protein-protein
H–I · 1243 Å² buried · 19 hydrogen bonds · protein-protein
C–D · 1218 Å² buried · 19 hydrogen bonds · protein-protein
F–J · 1216 Å² buried · 20 hydrogen bonds · protein-protein
G–H · 1214 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

1WX0 · Crystal structure of transaldolase from Thermus thermophilus HB8 · the same entry in another collection · chain J against J, TM-score 1.00
Q5SJE8 · AlphaFold monomer V2.0 prediction for probable transaldolase (Q5SJE8) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SJE8
Elsewhere: RCSB PDB 1WX0 · PDBe 1WX0 · UniProt Q5SJE8

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