MolNFT v1 · #26680 · protein

Crystal structure of CD14

1WWL · Monocyte differentiation antigen CD14: “Crystal structure of CD14”. X-ray diffraction, 1 ligand (NAG), 7 pockets (best druggability 0.79). MolNFT v1 #26680 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1WWL
Type: protein
Length: 620 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Monocyte differentiation antigen CD14
UniProt: P10810
Ligands: NAG
Pockets: 7 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 16% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Monocyte differentiation antigen CD14	protein	308	18% helix, 22% strand	P10810
B	Monocyte differentiation antigen CD14	protein	312	14% helix, 22% strand	P10810

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 10 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	742	0.79	0.83	49	empty
2	746	0.79	0.82	43	empty
3	125	0.68	0.89	21	empty
4	86	0.38	0.77	20	empty
5	76	0.38	0.77	19	empty

Interfaces

1 interface between chains.

A–B · 643 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 9 disulfide, 6 glycan (disulfide, N-glycosylation).

Compared structures

1WWL · Crystal structure of CD14 · the same entry in another collection · chain A against A, TM-score 1.00
P10810 · AlphaFold monomer V2.0 prediction for monocyte differentiation antigen CD14 (P10810) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10810
Elsewhere: RCSB PDB 1WWL · PDBe 1WWL · UniProt P10810

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