MolNFT v1 · #26654 · protein

Crystal structure of chitinase C from streptomyces griseus HUT6037

1WVU: “Crystal structure of chitinase C from streptomyces griseus HUT6037”. X-ray diffraction, 1 ligand (CL), 3 pockets (best druggability 0.69). MolNFT v1 #26654 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1WVU
Type: protein
Length: 462 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chitinase C
EC: 3.2.1.14
Ligands: CL
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chitinase C (EC 3.2.1.14)	protein	209	52% helix, 1% strand	—
B	Chitinase C (EC 3.2.1.14)	protein	253	42% helix, 9% strand	—

Ligands and binding sites

CL · Chloride ion · ion · 13 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	201	0.69	0.87	35	CL
2	265	0.68	0.83	31	empty
3	382	0.61	0.77	41	CL

Interfaces

1 interface between chains.

A–B · 1065 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

1WVU · Crystal structure of chitinase C from Streptomyces griseus HUT6037 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1WVU · PDBe 1WVU

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