MolNFT v1 · #26594 · protein

Crystal structure of molybdopterin biosynthesis moea protein from pyrococcus horikoshii OT3

1WU2: “Crystal structure of molybdopterin biosynthesis moea protein from pyrococcus horikoshii OT3”. X-ray diffraction, 7 pockets (best druggability 0.80). MolNFT v1 #26594 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1WU2
Type: protein
Length: 762 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Molybdopterin biosynthesis moea protein
Pockets: 7 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 21% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Molybdopterin biosynthesis moea protein	protein	383	21% helix, 32% strand	—
B	Molybdopterin biosynthesis moea protein	protein	379	21% helix, 32% strand	—

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	992	0.80	0.81	100	empty
2	874	0.75	0.79	88	empty
3	372	0.69	0.82	48	empty
4	152	0.47	0.77	30	empty
5	91	0.44	0.79	14	empty

Interfaces

1 interface between chains.

A–B · 3166 Å² buried · 33 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

1WU2 · Crystal Structure of molybdopterin biosynthesis moeA protein from Pyrococcus horikoshii… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1WU2 · PDBe 1WU2

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