MolNFT v1 · #26578 · protein

Comparison of crystal structures of two homologous proteins: structural origin of altered domain interactions in immunoglobulin light chain dimers

1WTL · Bence-jones protein mcg (light chain): “Comparison of crystal structures of two homologous proteins: structural origin of altered domain interactions…”. X-ray diffraction, 3 pockets (best druggability 0.37). MolNFT v1 #26578 on…

PDB: 1WTL
Type: protein
Length: 216 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bence-jones protein mcg (light chain)
UniProt: P80362
Pockets: 3 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Bence-jones protein mcg (light chain)	protein	108	3% helix, 51% strand	P80362

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	107	0.37	0.74	26	empty
2	62	0.28	0.74	18	empty
3	60	0.27	0.73	17	empty

Interfaces

1 interface between chains.

A–B · 710 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1WTL · Comparison of crystal structures of two homologous proteins: structural origin of altered… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P80362
Elsewhere: RCSB PDB 1WTL · PDBe 1WTL · UniProt P80362

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