MolNFT v1 · #26565 · protein

Coiled-coil domain of dmpk

1WT6 · Myotonin-protein kinase: “Coiled-coil domain of dmpk”. X-ray diffraction, 1 pocket (best druggability 0.52). MolNFT v1 #26565 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1WT6
Type: protein
Length: 195 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myotonin-protein kinase
EC: 2.7.1.-
UniProt: Q09013
Pockets: 1 · best druggability 0.52

Structure

x-ray diffraction · 3 distinct chains · 94% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myotonin-protein kinase (EC 2.7.1.-)	protein	65	94% helix, 0% strand	Q09013
B	Myotonin-protein kinase (EC 2.7.1.-)	protein	67	96% helix, 0% strand	Q09013
D	Myotonin-protein kinase (EC 2.7.1.-)	protein	63	94% helix, 0% strand	Q09013

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.52	0.83	25	empty

Interfaces

3 interfaces between chains.

A–B · 1289 Å² buried · 9 hydrogen bonds · protein-protein
B–D · 1277 Å² buried · 9 hydrogen bonds · protein-protein
A–D · 1201 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

1WT6 · Coiled-Coil domain of DMPK · the same entry in another collection · chain A against A, TM-score 1.00
Q09013 · AlphaFold monomer V2.0 prediction for myotonin-protein kinase (Q09013) · a predicted model of the same protein · chain D against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q09013
Elsewhere: RCSB PDB 1WT6 · PDBe 1WT6 · UniProt Q09013

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