MolNFT v1 · #26511 · protein

Crystal structure of TOM1 gat domain in complex with ubiquitin

1WRD · Target of myb protein 1: “Crystal structure of TOM1 gat domain in complex with ubiquitin”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #26511 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1WRD
Type: protein
Length: 174 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Target of myb protein 1; Ubiquitin
UniProt: O60784, P62990
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 2 distinct chains · 54% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Target of myb protein 1	protein	98	81% helix, 0% strand	O60784
B	Ubiquitin	protein	76	20% helix, 34% strand	P62990

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	54	0.37	0.80	13	empty

Interfaces

1 interface between chains.

A–B · 612 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1WRD · Crystal structure of Tom1 GAT domain in complex with ubiquitin · the same entry in another collection · chain A against A, TM-score 1.00
O60784 · AlphaFold monomer V2.0 prediction for target of myb protein 1 (O60784) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60784
Every structure of UniProt P62990
Elsewhere: RCSB PDB 1WRD · PDBe 1WRD · UniProt O60784 · UniProt P62990

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